|Awarded On||August 20, 2014|
|Title||Natural Product for Treatment of Non Small Cell Lung Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||John MacMillan|
|Cancer Sites||Breast, Lung and Bronchus|
This proposal aims to develop a novel therapeutic for the treatment of lung cancer, which is the largest cancer killer of both men and women in the United States. The development of therapies targeted to specific mutations in cancer, such as EGFR mutations in lung cancer, has greatly increased our ability to treat cancer. We have discovered a natural product from a marine-derived bacteria, called discoipyrrole A, that selective kills cancer cells that have oncogenic mutations in a protein called the discoidin domain receptor 2. These mutations are present in about 4% of squamous cell carcinomas, a percentage similar to EML4-ALK fusion and other targeted mutations. We will use a combination o...