Grant ID RP140181
Awarded On August 20, 2014
Title Mechanisms of CTC Biomarkers in Breast Cancer Brain Metastasis
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The Methodist Hospital Research Institute
Principal Investigator/Program Director Dario Marchetti
Cancer Sites Brain and Other Nervous System, Breast
Contracted Amount $621,329.51
Award Transfer Information

Previous Organization: Baylor College of Medicine

Expended at Previous Organization: $278,638.49

Lay Summary

Circulating tumor cells (CTCs) are a necessary pre-condition for metastasis to occur. CTCs shed from the primary tumor circulate and survive in the blood, arrest/adhere at distant organ sites, and extravasate at the target organ site to generate metastasis. This proposal is designed to reveal fundamental characteristics of breast cancer brain-colonizing CTCs. We have discovered patient-derived CTCs that possess high competency for breast cancer brain metastasis (BCBM). Importantly, these CTCs go undetected by the current FDA-approved CellSearchTM CTC test that can be “blind” to potentially the most dangerous cancer cells present in the circulation. We have formulated the hypothesis that the ...

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