|Awarded On||August 20, 2014|
|Title||Direct Roles for RB and E2F1 in DNA Repair|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||David Johnson|
|Cancer Sites||All Sites|
The retinoblastoma (RB) gene was the first tumor suppressor to be cloned almost 30 years ago. It is now known that RB is mutated not only in retinoblastomas but also in other cancers, including cancers of the bone and lung. Moreover, the RB protein is functionally inactivated in many cancers through other mutations or by the action of viruses, as is the case in most cervical cancers. Taken together, loss of RB function occurs in most tumors and is considered a hallmark of cancer. The RB protein binds to and inhibits the activity of the E2F1 transcription factor. E2F1 regulates the expression of genes important for cell proliferation and RB is widely believed to function as a tumor suppressor...