Grant ID RP140223
Awarded On August 20, 2014
Title Viral MicroRNAs in Ovarian Cancer Growth and Metastasis
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Matthew L Anderson
Cancer Sites Ovary
Contracted Amount $199,995
Lay Summary

Nearly 15% of all human cancers are caused by viral infections. Examples of viruses and the cancers they cause include the human papilloma virus (cervical, nasopharyngeal and anal cancers), Epstein-Barr virus (nasopharyngeal cancers and lymphomas), and hepatitis C virus (liver cancer). Viral infections are not currently thought to play any significant role in most other human cancers. Recently, we discovered that specific microRNAs encoded by Epstein-Barr virus (EBV) and cytomegalovirus (HCMV) are robustly associated with ovarian cancer outcomes. MicroRNAs (miRNAs) are evolutionarily conserved, small RNA transcripts 22-24 nucleotides in length. In humans and other mammals, miRNAs play a crit...

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