|Awarded On||August 20, 2014|
|Title||Viral MicroRNAs in Ovarian Cancer Growth and Metastasis|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Matthew L Anderson|
Nearly 15% of all human cancers are caused by viral infections. Examples of viruses and the cancers they cause include the human papilloma virus (cervical, nasopharyngeal and anal cancers), Epstein-Barr virus (nasopharyngeal cancers and lymphomas), and hepatitis C virus (liver cancer). Viral infections are not currently thought to play any significant role in most other human cancers. Recently, we discovered that specific microRNAs encoded by Epstein-Barr virus (EBV) and cytomegalovirus (HCMV) are robustly associated with ovarian cancer outcomes. MicroRNAs (miRNAs) are evolutionarily conserved, small RNA transcripts 22-24 nucleotides in length. In humans and other mammals, miRNAs play a crit...