Grant ID RP140224
Awarded On August 20, 2014
Title PPAR-Delta Regulation of Wnt/B-Catenin To Drive Colon Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Imad Shureiqi
Cancer Sites Colorectal
Contracted Amount $890,003
Lay Summary

Colon cancer is the second most common cause of cancer death in the United States. Despite progress in prevention and treatment of colon cancer, the 5-year death rate from this disease remains almost 40%. Clearly, better measures to treat and prevent colon cancer are needed. Improved understanding of the mechanisms underlying the formation of colon cancer will provide key information needed to develop new treatment and preventive measures for this commonly fatal disease. Levels of the protein PPAR-d (peroxisome proliferator-activated receptor-delta) are increased in human colon cancer cells. However, the role of PPAR-d in colon cancer and other types of cancer remains unclear. Clarifying the...

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