Grant ID RP140233
Awarded On August 20, 2014
Title Structure-Guided Kinase Inhibitor Design for Cancer Therapy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Kenneth Westover
Cancer Sites All Sites
Contracted Amount $900,000
Lay Summary

Small molecule inhibitors are powerful tools for understanding cell physiology and validating drug targets for the treatment of a variety of diseases, especially cancer. Modern drug discovery often begins with the identification of cellular targets followed by chemical compound development. Translation of hypothetical drug targets into pharmacological proof-of-concept studies is a major bottleneck because production of new classes of small molecule inhibitors requires many lines of expertise including chemistry, enzymology, structural biology, cell biology and disease modeling in animals. Large collaborations enable the needed progress. We belong to a collaborative group with a track record ...

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