Grant ID RP140298
Awarded On August 20, 2014
Title Engineering Microfluidic Devices for Multimodal Mechanical Phenotyping of Tumor Cells in Flow
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Texas Tech University
Principal Investigator/Program Director Siva Vanapalli
Cancer Sites All Sites
Contracted Amount $674,465
Lay Summary

Everyone knows that honey is thicker than water, but how thick are cancer cells? Supported by a 2009 CPRIT High Impact High Risk Award, we measured the viscosity of cancer cells using a miniaturized cell squeezer device. We unexpectedly found that highly metastatic (HM) cells are viscous, like honey and non-metastatic cells are almost like water. Motivated by these findings, we propose to engineer two novel devices – a microfluidic cell fragmenter (MCF) and a microfluidic cell occluder (MCO). The MCF device breaks cells apart, allowing us to test our hypothesis that HM cells should be difficult to break because of their higher viscosity. The MCO device measures clogging properties of tumor c...

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