|Awarded On||August 20, 2014|
|Title||Engineering Microfluidic Devices for Multimodal Mechanical Phenotyping of Tumor Cells in Flow|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Texas Tech University|
|Principal Investigator/Program Director||Siva Vanapalli|
|Cancer Sites||All Sites|
Everyone knows that honey is thicker than water, but how thick are cancer cells? Supported by a 2009 CPRIT High Impact High Risk Award, we measured the viscosity of cancer cells using a miniaturized cell squeezer device. We unexpectedly found that highly metastatic (HM) cells are viscous, like honey and non-metastatic cells are almost like water. Motivated by these findings, we propose to engineer two novel devices – a microfluidic cell fragmenter (MCF) and a microfluidic cell occluder (MCO). The MCF device breaks cells apart, allowing us to test our hypothesis that HM cells should be difficult to break because of their higher viscosity. The MCO device measures clogging properties of tumor c...