Grant ID RP140320
Awarded On August 20, 2014
Title Dissecting a Necrotic Signaling Pathway in Human Cancer Cells
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Qing Zhong
Cancer Sites Breast, Ovary, Pancreas, Prostate
Contracted Amount $200,000
Lay Summary

One of the ultimate goals of cancer therapy is to kill cancer cells without sacrificing normal cells. However, cancers cells are often resistant to apoptosis, the major form of cell death. Recent studies suggest that apoptosis-resistant cells are prone to non-apoptotic necrotic cell death, an alternative form of cell death. Therefore, necrosis activation could function as a novel means to selectively kill cancer cells versus normal cells. However, it is still not fully understood how necrosis is controlled. In our preliminary study, we found a small molecule compound, originally identified from a screen for anti-cancer agents, directly activates necrosis based on rigorous measurements by dif...

Read More