Grant ID RP140323
Awarded On August 20, 2014
Title Role of a Novel Histone Variant-Specific Epigenetic Reader ZMYND11 in Breast Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Xiaobing Shi
Cancer Sites Breast
Contracted Amount $899,534
Lay Summary

Our genetic information is stored in DNA. In eukaryotes, DNA does not exist in a free state, but rather is packaged by proteins called histone into the higher-order structure, namely chromatin. This kind of architecture allows dynamic control of the underlying DNA to be expressed at an appropriate time. The histone proteins are heavily modified, i.e. adding chemical groups such as methyl or acetyl to the amino acids of histones, which renders another layer of regulation. The methyl groups on histones function as platforms to recruit protein factors called readers, which in turn bring additional proteins to modulate chromatin structure and the accessibility of the underlying DNA. This researc...

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