Grant ID RP140328
Awarded On August 20, 2014
Title Synthetic Protein Degradation Agents To Clear Oncogenic Proteins From Cells
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Andreas Matouschek
Cancer Sites All Sites
Contracted Amount $199,852
Lay Summary

A hallmark of cancer is the presence of proteins that inappropriately signal cells to grow and to divide. We are developing a strategy to purge such oncogenic proteins from cells by taking advantage of the cells’ own protein removal system. Cancer cells can be addicted to oncogenic proteins and die when they no longer receive the growth stimulus from these proteins. For example, the drug Gleevec kills cancer cells by inhibiting the oncogenic protein Bcr-Abl from sending its growth signal. Thus, clearing oncogenic proteins from cells could be a novel strategy for molecularly targeted therapeutics. Cells constantly remove proteins that are unwanted and much of this protein removal occurs by th...

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