Grant ID RP140367
Awarded On August 20, 2014
Title Targeting BRD4 in Breast Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Cheng-Ming Chiang
Cancer Sites Breast
Contracted Amount $900,000
Lay Summary

Treatment of breast cancer based on histological diagnosis and detection of molecular markers present in cancer cells has been valuable in designing appropriate regimens for targeted therapy. Nevertheless, the clinical outcome remains uncertain due to the heterogeneity of tumor microenvironments and the genetic traits of individuals. Even though high-throughput sequencing technology has made it possible to profile an individual’s genome for personalized medicine, many cancer-driver genes and their expression patterns often exhibit an undetectable or minor difference between cancer and normal cells. This highlights the need for developing new diagnosis and prognosis strategies. Recently, two ...

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