|Awarded On||August 20, 2014|
|Title||Targeting Tumor Cell Invasion in Glioblastoma|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Joseph McCarty|
|Cancer Sites||Brain and Other Nervous System|
Gliomas are devastating malignancies that afflict approximately 15,000 people within the United States each year. They represent the most common types of primary brain tumor, and in their advanced stages they are one of the deadliest forms of cancer. Most high-grade gliomas, and particularly glioblastomas (GBMs), are refractory to standard surgical, radiation, and chemotherapeutic interventions. Survival rates have changed little in the last few decades; nearly 100% of patients will succumb to the disease within three years after diagnosis. GBM remains incurable because of its highly invasive and infiltrative growth properties. Single cells are able to invade far away from the primary tumor ...