Grant ID RP140430
Awarded On August 20, 2014
Title Synaptic Mechanisms of Cognitive Decline After Cranial Radiation
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director David Grosshans
Cancer Sites Brain and Other Nervous System, Childhood and Adolescent
Contracted Amount $836,557
Lay Summary

Cure rates for childhood brain tumors have greatly improved over the past few decades; indeed, for some brain tumors nearly 8 of 10 children are cured. Combined treatment approaches using surgery, chemotherapy, and radiation are largely responsible for these improved outcomes. Unfortunately, many survivors live with lifelong side effects from the treatment itself. Radiation therapy to the brain is particularly damaging for young children. When large regions of the brain are treated with radiation, the patients’ intelligence and quality of life decline. Despite attempts to reduce radiation doses or even omit radiation, this therapy remains essential—without radiation therapy, tumors recur and...

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