|Awarded On||August 20, 2014|
|Title||Synaptic Mechanisms of Cognitive Decline After Cranial Radiation|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||David Grosshans|
|Cancer Sites||Brain and Other Nervous System, Childhood and Adolescent|
Cure rates for childhood brain tumors have greatly improved over the past few decades; indeed, for some brain tumors nearly 8 of 10 children are cured. Combined treatment approaches using surgery, chemotherapy, and radiation are largely responsible for these improved outcomes. Unfortunately, many survivors live with lifelong side effects from the treatment itself. Radiation therapy to the brain is particularly damaging for young children. When large regions of the brain are treated with radiation, the patients’ intelligence and quality of life decline. Despite attempts to reduce radiation doses or even omit radiation, this therapy remains essential—without radiation therapy, tumors recur and...