Grant ID RP140435
Awarded On August 20, 2014
Title SHH/GLI3 Signaling Axis as a Therapeutic Target in Castration Resistant Prostate Cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Thomas Boyer
Cancer Sites Prostate
Contracted Amount $200,000
Lay Summary

Prostate cancer is the most common malignancy and the second leading cause of cancer-associated deaths among US men. Although most prostate cancer patients initially respond to androgen deprivation therapy, they eventually progress to castration resistant prostate cancer (CRPC) characterized by androgen receptor-dependent tumor growth despite castrate levels of circulating androgens. Once patients have reached this stage, treatment options are frustratingly limited and average survival times range from 2-3 years only. Therefore, one of the overarching challenges in the field is to develop effective treatments and address mechanisms of CRPC. This innovative proposal conforms precisely to this...

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