Grant ID RP140452
Awarded On August 20, 2014
Title Inactivating Mutation of D2HGDH Establishes a Novel Link Between Metabolism, Alpha-KG Dependent Dioxygenases and Epigenetic Reprograming in B Cell Lymphoma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Ricardo Aguiar
Cancer Sites Lymphoma
Contracted Amount $854,740
Lay Summary

Cancer cells have a unique metabolism. However, debate still exists as to whether this altered cellular metabolism can cause cancer, or if it is simply a byproduct of the fast growth pattern that typifies malignant cells. Studying B cell lymphomas, we discovered the presence of inactivating mutations in the gene D2HGDH, which encodes an important metabolic enzyme. This finding supported the idea that metabolic aberrations can directly cause cancer. To start to examine how inactivation of D2HGDH may contribute to the development and/or maintenance of tumor cells, we quantified the molecules that are processed by this enzyme. Cells containing the defective D2HGDH gene had abnormally lower leve...

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