|Awarded On||August 20, 2014|
|Title||Inactivating Mutation of D2HGDH Establishes a Novel Link Between Metabolism, Alpha-KG Dependent Dioxygenases and Epigenetic Reprograming in B Cell Lymphoma|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Ricardo Aguiar|
Cancer cells have a unique metabolism. However, debate still exists as to whether this altered cellular metabolism can cause cancer, or if it is simply a byproduct of the fast growth pattern that typifies malignant cells. Studying B cell lymphomas, we discovered the presence of inactivating mutations in the gene D2HGDH, which encodes an important metabolic enzyme. This finding supported the idea that metabolic aberrations can directly cause cancer. To start to examine how inactivation of D2HGDH may contribute to the development and/or maintenance of tumor cells, we quantified the molecules that are processed by this enzyme. Cells containing the defective D2HGDH gene had abnormally lower leve...