Grant ID RP140456
Awarded On August 20, 2014
Title Role of DNA2 Nuclease in Cellular Tolerance of Replication Stress and Telomere Maintenance - Implications for Cancer Biology and Anticancer Therapy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Grzegorz Ira
Cancer Sites All Sites
Contracted Amount $746,531
Lay Summary

The key to successful targeted cancer therapy is to identify intrinsic features that distinguish cancer cells from normal cells. Cancer specific unlimited proliferation signals, due to the activation of the oncogenes or loss of tumor suppressors, result in immortalization. The consequences of unlimited proliferation include loss of chromosome ends, called telomeres, and largely increased spontaneous DNA damage associated with uncontrolled chromosomes duplication. To counteract these processes, cancer cells increase the usage of a specific DNA repair pathway called Break-Induced Replication, which helps cells to repair frequent chromosome breaks and, in some cancers types such as sarcomas, he...

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