|Awarded On||August 20, 2014|
|Title||Systematic Investigation of Clinically Relevant Expressed Pseudogenes in Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Han Liang|
|Cancer Sites||All Sites|
Once thought of as “junk DNA,” pseudogenes are a large class of DNA molecules that have lost their ability to generate functional protein products. Of >18,000 human pseudogenes, a large proportion is transcribed into RNA molecules, which means that many pseudogenes are expressed at the RNA level. Although recent studies strongly suggest potential roles for several individual pseudogenes in tumor biology, pseudogenes represent one of the most understudied topics in the field of cancer research. Little is known about how this class of molecules contributes to the development of tumors and how they can be used to attack tumor cells. The overall goal of this project is to systematically identify...