|Awarded On||August 20, 2014|
|Title||Next Generation Sequencing and Transcriptome Profiling of Oral Potentially Malignant Lesions To Identify Markers of Cancer Risk and Targets for Chemoprevention|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Jianjun Zhang|
|Cancer Sites||Head and Neck|
Many oral cancers arise from non-cancerous sores in the mouth termed oral potentially malignant lesions (OPMLs). While the presence of OPMLs places an individual at increased risk of oral cancer, not all OPMLs develop into cancer. Because OPMLs occur in areas that are easily followed by examination, readily biopsied for pathological evaluation, and are precursors of cancer, they are considered to be an ideal source to study molecular changes that eventually cause malignant tumors. Furthermore, they provide a unique opportunity for chemoprevention studies (i.e., use of drugs to reduce cancer risk), as patients with OPMLs have a higher probability of being diagnosed with oral cancers, but have...