|Awarded On||August 20, 2014|
|Title||Investigation of the Tumor Suppressor TMEM127 on Lysosome Function and Lipid Metabolism|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Patricia L Dahia|
|Cancer Sites||All Sites|
Obesity is associated with increased cancer risk and understanding the processes involved in control of body weight can have an impact in reducing this risk. The lysosome, a cell organelle better known for its clearance of degraded proteins and other cell particles and often referred to as the cell sink, has recently been recognized as a critically important signaling center that synchronizes the response to nutrients, including fat, with cellular function and growth. We previously identified the novel tumor suppressor gene TMEM127 to be mutated in hereditary cancers and found that this gene is located in the lysosome. We have now developed a mouse model of TMEM127 inactivation and determine...