|Awarded On||August 20, 2014|
|Title||Preclinical Intravital Microscopy of Prostate Cancer Lesions in Bone: Identification and Eradication of Survival Niches by Combination Therapy|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Eleonora Dondossola|
Bone metastases are a major complication in patients with advanced prostate cancer (PCa). After colonizing bone, PCa cells lead to its remodelling, followed by symptoms and detrimental consumption of the organism. At this stage, PCa disease is usually incurable. Despite recent encouraging results obtained with innovative cures, including radiation and molecular therapy, the benefit for patients is often incomplete and limited in duration. Such therapy resistance occurs when tumor cells adapt to anticancer treatments and escape from death, re-initiating tumor growth. With this project we establish a bone-window mouse model suited for monitoring by microscopy to investigate (i) how PCa cells g...