|Awarded On||August 20, 2014|
|Title||Optimal Biomarkers for Personalized Cancer Therapy: A Network-Based Approach|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Mathukumalli Vidyasagar|
|Cancer Sites||Breast, Lung and Bronchus, Ovary|
Cancer is the most individual of diseases, in that no two instances of the disease are alike, even when they occur in the same organ. 'Personal medicine' refers to stratifying patients into small groups so that the treatment can be fine-tuned to be most effective for each group. In this project we will develop several tools for personal medicine, with emphasis on four specific forms of cancer: ovarian, endometrial, breast and lung. For endometrial tumors larger than 2 cm in diameter, the recommended procedure is to remove not just the uterus but also the pelvic lymph nodes. However, 78% of lymph node surgeries are unnecesssary. We have identified 13 parameters to identify most of the patient...