|Awarded On||August 20, 2014|
|Title||Mapping Acidic Tumor Microenvironment With Renal Clearable pH Nanoindicators|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Jie Zheng|
|Cancer Sites||All Sites|
While local extracellular pH (pHe) of solid tumors is just slightly acidic compared to that of normal tissues, this tiny pH difference promotes cancer initiation, progression and metastasis, strongly affects cancer cell resistance to anticancer drugs such as Doxorubicin (DOX) and serves as a key target in cancer treatment. Since the peritumoral pH is highly heterogeneous in spatial distribution and not completely overlapped with tumor margin, imaging of acidic tumor environment (TAM) at high spatial resolution and high contrast is critical to fundamental understandings of cancer invasion, predication of cancer development and evaluation therapeutic effectiveness but remains a long-term chall...