|Awarded On||August 20, 2014|
|Title||Translational Discovery of Resistance Genes and Cancer Gene Functions|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Susan Rosenberg|
|Cancer Sites||Breast, Colorectal, Head and Neck, Lung and Bronchus, Pancreas, Stomach|
Most cancer deaths result not from cancer itself but from cancers that have evolved resistance to our chemotherapies. Resistance is caused by mutations in genes. Some of these mutations are present in tumors before chemotherapy is undertaken, making particular therapies doomed to failure in some tumors before they are started. If we could distinguish which tumors were already resistant to specific drugs, we could give the right drugs for each patient. Ineffective drugs allow development of more resistances to additional therapies as cancers continue to grow, mutate and evolve. The goal of this project is to identify which genes cause resistance to one of the most commonly used anti-cancer dr...