Grant ID RP140563
Awarded On August 20, 2014
Title PAF, a Novel Wnt Signaling Regulator, in Colorectal Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Jae-Il Park
Cancer Sites Colorectal
Contracted Amount $900,000
Lay Summary

Background Cellular signalings play crucial roles in tissue maintenance and regeneration. Conversely, deregulated cellular signalings leads to human cancer. Among those cellular signalings, we have consistently studied Wnt signaling, which controls cell proliferation. Genetic mutation in Wnt signaling lead to abnormal hyperactivation of Wnt signaling, results in accelerated cell proliferation and subsequent colorectal cancer. Thus, elucidating the regulatory mechanisms of Wnt signaling to allow for its targeted manipulation will thus provide a milestone in colorectal cancer research and treatment. Previous Studies Recently, we revealed unexpected roles of PAF, a protein required for DNA repa...

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