|Awarded On||August 20, 2014|
|Title||PAF, a Novel Wnt Signaling Regulator, in Colorectal Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Jae-Il Park|
Background Cellular signalings play crucial roles in tissue maintenance and regeneration. Conversely, deregulated cellular signalings leads to human cancer. Among those cellular signalings, we have consistently studied Wnt signaling, which controls cell proliferation. Genetic mutation in Wnt signaling lead to abnormal hyperactivation of Wnt signaling, results in accelerated cell proliferation and subsequent colorectal cancer. Thus, elucidating the regulatory mechanisms of Wnt signaling to allow for its targeted manipulation will thus provide a milestone in colorectal cancer research and treatment. Previous Studies Recently, we revealed unexpected roles of PAF, a protein required for DNA repa...