|Awarded On||August 20, 2014|
|Title||Tenascin-C and Metastatic Prostate Cancer Progression|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||David Rowley|
Prostate cancer primarily metastasizes to bone and is difficult to treat effectively. The processes that control the ability of prostate cancer cells to attach to bone, to form colonies, and to grow to larger is not understood. We have found that there are increases in the tenascin-C protein at sites where metastatic prostate cancer forms in the internal bone. The bone cells lining the bone surface adjacent to cancer cells produce tenascin-C. Tenascin-C is a secreted protein that is part of the matrix of proteins deposited outside the cell onto the bone surface. Important to our study, tenascin-C affects cancer cell adhesion, migration, invasion, proliferation and protects cancer cells from ...