|Awarded On||August 20, 2014|
|Title||Analyses of the Regulatory Mechanisms of Tankyrase and Its Role in Tumorigenesis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Xuewu Zhang|
|Cancer Sites||Colorectal, Lung and Bronchus, Prostate|
Tankyrases are members of a group of enzymes called PARPs, which modify their target proteins by adding one or a polymer chain of the ADP-ribose group. This modification regulates various aspects of many proteins, including their biological activity and destruction. Through this modification, tankyrase controls several important cellular processes such as cell proliferation and telomere homeostasis. Dysregulation of these processes is often associated with cancer. Therefore, inhibition of tankyrases by small molecule inhibitors is a promising strategy for targeted cancer therapy. However, side effects of current inhibitors of tankyrases, due mainly to off-target inhibition of other PARP fami...