Grant ID RP140767
Awarded On August 20, 2014
Title Toll-Like Receptors, Gut Microbiota, and Risk of Colorectal Adenoma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Li Jiao
Cancer Sites Colorectal
Contracted Amount $899,131
Lay Summary

Colorectal cancer (CRC) remains the 3rd leading cancer killer in Texas and the U.S. More than 90% of CRCs arise from pre-cancerous polyps known as colorectal adenoma (CRA). Diet is a modifiable risk factor for CRA and CRC. Understanding the cause of this link may provide a novel opportunity for preventing CRC. Toll-like receptors (TLRs) are present on the lining of cells in the colon. TLRs recognize bacterial and dietary components like fatty acid and transmit signals to our body initiating an inflammatory response. The delicate balance among diet, gut microbiota (i.e., a population of greater than 100 trillion microorganisms living in our gut) and TLRs is critical in maintaining colon healt...

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