Grant ID RP140784
Awarded On August 20, 2014
Title Next Generation Sequencing-Based Approaches for the Development of Epigenetic Biomarkers for Predicting Therapeutic Outcome in Patients With Colorectal Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Ajay Goel
Cancer Sites Colorectal
Contracted Amount $886,982
Lay Summary

Colorectal cancer (CRC) is one of the most common cancers worldwide; and is the second-leading cause of cancer-related deaths in the United States, with an estimated 50,000 deaths annually. For patients with more advanced disease, chemotherapeutic treatments are unavoidable. In spite of the advances we have made in the recent years, we have not been very successful in developing chemotherapeutic drugs that are predictively safe, effective and non-toxic. At the moment we have few individualized treatment options for CRC patients, and most patients end up receiving similar treatments, which may provide benefit, or perhaps harm. Over the years we have learned that individual CRCs are quite diff...

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