Grant ID RP140800
Awarded On August 20, 2014
Title The Role of Alternative Polyadenylation in Glioblastoma Tumor Progression
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Medical Branch at Galveston
Principal Investigator/Program Director Eric J Wagner
Cancer Sites Brain and Other Nervous System
Contracted Amount $724,772.28
Award Transfer Information

Previous Organization: The University of Texas Health Science Center at Houston

Expended at Previous Organization: $123,718.72

Lay Summary

Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor. The unfortunate combination of its infiltrative growth and aggressive phenotype prevents virtually any positive clinical outcome. The Cancer Genome Atlas project has devoted significant efforts to characterize mutations associated with GBM but due to the bias towards exome sequencing, correlations between survival and changes in epigenetics, intergenic regions, and UTRs have not been thoroughly investigated. At the heart of this proposal are these examples of so-called “dark matter” present within the cancer genomics landscape. Alternative polyadenylation (APA) represents an exciting paradigm in gene expression regul...

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