Grant ID RP140842
Awarded On August 20, 2014
Title Determining the Functional Role of microRNAs in Viral Tumorigenesis
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Christopher S Sullivan
Cancer Sites Cervix Uteri, Head and Neck, Leukemia, Lymphoma, Sarcoma, Skin
Contracted Amount $604,624
Lay Summary

It is underappreciated that a share of human cancers are caused by virus infection. These cancers include types of lymphomas, skin cancers, oral tumors and cervical carcinomas. A new class of gene products of both host and viral origin, called microRNAs, plays an important role in helping most of these viruses maintain lifelong infections. Furthermore, mounting evidence suggests that microRNAs of both host and viral origin are directly involved in tumorigenesis. However, the current understanding of how tumor viral microRNAs contribute to cancer lags behind that of host microRNAs. The goal of this application is to determine how tumor viruses utilize microRNAs to promote infection and cause ...

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