|Awarded On||August 20, 2014|
|Title||Determining the Functional Role of microRNAs in Viral Tumorigenesis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||Christopher S Sullivan|
|Cancer Sites||Cervix Uteri, Head and Neck, Leukemia, Lymphoma, Sarcoma, Skin|
It is underappreciated that a share of human cancers are caused by virus infection. These cancers include types of lymphomas, skin cancers, oral tumors and cervical carcinomas. A new class of gene products of both host and viral origin, called microRNAs, plays an important role in helping most of these viruses maintain lifelong infections. Furthermore, mounting evidence suggests that microRNAs of both host and viral origin are directly involved in tumorigenesis. However, the current understanding of how tumor viral microRNAs contribute to cancer lags behind that of host microRNAs. The goal of this application is to determine how tumor viruses utilize microRNAs to promote infection and cause ...