|Awarded On||February 18, 2015|
|Title||Elucidating the evolution of the premalignant airway genome in space and time|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Humam Kadara|
|Cancer Sites||Lung and Bronchus|
Lung cancer is the leading cause of cancer death worldwide. Lung adenocarcinoma represents the majority of lung cancers found in patients and the cure rate for this disease has not improved. There are over 90 million former and current smokers in the United States at elevated risk for lung adenocarcinoma and the epidemic of this fatal disease will remain long after smoking incidence has dropped. We still do not know how to choose the appropriate drugs to prevent the onset of lung adenocarcinomas in this high-risk population. It is widely appreciated that genetic changes in DNA provide tumors with the ability to grow and expand. Yet, very little is known about genomic changes that lead to the...