|Awarded On||February 18, 2015|
|Title||Role of PTEN feedback mechanism in cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Min Sup Song|
|Cancer Sites||Breast, Prostate, Thyroid|
Over four decades ago, Alfred G. Knudson proposed a ground-breaking model for tumorigenesis, suggesting that cancer is a consequence of genetic mutations that inactivate specific genes which suppress the growth of cancer cells. This visionary working model has greatly advanced our understanding of cancer, and has directly led to the discovery of numerous tumor suppressor genes, including PTEN (phosphatase and tensin homolog). PTEN was found to be frequently disrupted in multiple sporadic tumor types, and mutated in the germlines of patients with cancer predisposition syndromes such as Cowden disease. PTEN protein is known to govern a plethora of cellular processes, including cell survival, p...