|Awarded On||February 18, 2015|
|Title||Genome stability and immune diversity controlled by the POLQ pathway|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Kevin McBride|
|Cancer Sites||All Sites|
Genetic alterations are fundamental in cancer development. These arise frequently after the DNA in our chromosomes is damaged and broken. Such damage can occur when cells are exposed to background or medical radiation. Breaks are also introduced into DNA during normal processes that generate our immune systems. Such breaks can be dangerous, leading to deletions within genes, or to rearrangements between chromosomes. To defend against harmful consequences of DNA breaks, cells have mechanisms to repair them. This proposal deals with a new mechanism for DNA break repair that we have discovered, controlled by an enzyme called POLQ. The POLQ-dependent repair process has profound consequences. Fi...