Grant ID RP150164
Awarded On February 18, 2015
Title Using imaging and computational tools to improve risk stratification in children with bone cancer
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Patrick Leavey
Cancer Sites Bone, Childhood and Adolescent, Sarcoma
Contracted Amount $1,290,442
Lay Summary

Osteosarcoma is the most common bone cancer in children and young adults but at least 40% of patients die of this disease. There is an urgency and critical need to identify accurately and as early as possible those patients at high risk of dying. Basic features of tumor spread and if the tumor is surgically removable identify such patients, while poor tumor response to 10 weeks of chemotherapy is another high-risk feature. Unfortunately identifying these features has not yet allowed effective change in therapy to improve patient survival. Yet, since tumor response in other childhood cancers allows effective tailoring of therapy, we believe that the inability to achieve improvements for patie...

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