|Awarded On||February 18, 2015|
|Title||Prostate Cancer Chemoprevention with Resveratrol|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Addanki Kumar|
In this proposal we are testing the ability of Resveratrol (RES) present in grapes, nuts and berries to prevent the progression of high-grade PIN (HGPIN) to clinical prostate cancer. Men who have HGPIN lesions in their prostate are at a high risk of developing clinical prostate cancer. This process takes many years therefore it is feasible to target disease progression with chemopreventive agents. Our laboratory has a rich history of testing naturally occurring chemicals from botanicals as chemopreventive agents. Published population-based case control studies showed a statistically significant decrease in relative prostate cancer risk in men consuming red wine, which also contains RES. Howe...