|Awarded On||February 18, 2015|
|Title||The Role of Progesterone Receptor in Early Stage Breast Cancer.|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Dean P Edwards|
The estrogen receptor (ER) signaling axis stimulates growth and progression of human breast cancers and targeted anti-estrogen therapies are a standard of care treatment of ER+ tumors. However, it has become increasingly appreciated that the other ovarian steroid hormone progesterone (P4) also plays a role in breast tumorigenesis but progesterone receptor (PR) has not been fully exploited as a therapeutic target. During the reproductive years of women, P4 stimulates continuous cycles of proliferation of breast luminal epithelial cells. Clinical studies and other epidemiological studies indicate that P4 is a risk factor for breast cancer. A number of experimental mouse mammary tumor models ha...