|Awarded On||February 18, 2015|
|Title||Functional and structural characterization of a small chemical compound that arrests glioma stem cell growth with high activity and specificity|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jef K De Brabander|
|Cancer Sites||Brain and Other Nervous System|
Glioblastoma multiforme (GBM) is the most common type of malignant brain cancer and is incurable. Therefore, there is a critical need to identify new ways of investigating and attacking this disease. The Cancer Genome Atlas Project, a multi-institutional effort to study the DNA of cancers in the hopes of finding common mutations that may indicate new targets for developing therapies identified mutation combinations of a dozen or so genes previously associated with cancer in GBM. Of these, three cancer associated genes: p53, NF1 and Pten were among the five most frequently mutated GBM associated genes. We have constructed genetically engineered mice that harbor the above three mutations and t...