|Awarded On||February 18, 2015|
|Title||Broad Shortening of 3' UTRs in Human Cancers: Methods, Target Genes and Functional Consequences|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Wei Li|
|Cancer Sites||All Sites|
For more than 70% of human genes, their three prime untranslated regions (3? UTR) can be shortened under diverse physiological conditions. Since 3’ UTRs contain many important cis-regulatory elements, such as miRNA binding sites, gene with shorter 3’ UTRs will no longer be repressed by miRNA, leading to higher expression. The role of 3’ UTR in human cancers is only beginning to be appreciated. Both proliferating and transformed cells have been shown to favor shortened 3? UTRs, leading to activation of proto-oncogenes. In addition, our recent study (Nature in press) identified CFIm25, a master 3’ UTR regulator, as a glioblastoma (GBM) tumor suppressor, further underscoring the importance of 3...