|Awarded On||February 18, 2015|
|Title||Identification of clinically relevant targets for radiosensitization|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Heath Skinner|
|Cancer Sites||Head and Neck|
The treatment for head and neck cancer usually involves radiotherapy. However, right now there is only one commonly used drug that specifically targets an alteration in the tumor that makes it resistant to radiotherapy. More drugs like this are needed. This project will look at 50 cell lines from head and neck tumors in a broad way to see if any mutation, gene or protein is highly associated with resistance to radiation. We will also use an animal model of head and neck cancer to screen hundreds of proteins that may be related to resistance to radiotherapy and that can be targeted using existing drugs. Following these studies, we will then determine if any targets derived from the above stud...