Grant ID RP150301
Awarded On February 18, 2015
Title Epigenetics in Medulloblastoma Development and Therapeutics
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Vidya Gopalakrishnan
Cancer Sites Brain and Other Nervous System, Childhood and Adolescent
Contracted Amount $1,871,708
Lay Summary

Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Although significant improvements have been made in 5-year survival rates in the past decade, survivors continue to be at substantial risk for recurrence and metastasis. Unfortunately the outcome for these patients is dismal as there are no therapeutic options available at this time. An incomplete knowledge of tumor biology and molecules that drive tumorigenesis has significantly hampered efforts to develop new treatments. The current focus on tumor genetics by many groups has yielded only a few druggable targets. In contrast, abnormalities in the tumor cell chromatin architecture or epigenome can be reversed pharmacologically...

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