|Awarded On||February 18, 2015|
|Title||Personalized Functionalization of Pediatric High Grade Glioma|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Benjamin Deneen|
|Cancer Sites||Brain and Other Nervous System|
A major effort in cancer research is focused on identifying genes directly responsible for promoting cancer progression (referred to here as "drivers"). The identification of driver genes and characterization of their function has been the moving force behind much of the recent progress in cancer treatment. Driver identification is particularly important for aggressive cancers such as pediatric high grade glioma (PHGG), which represents 10% of all pediatric brain tumors. Most children diagnosed with PHGG receive a dismal prognosis, as the disease carries a 5 year survival rate of <5%. Recent studies at the Baylor College of Medicine characterized the full spectrum of gene mutati...