|Awarded On||February 18, 2015|
|Title||Targeting Twist1 for Prevention and Treatment of Non-Melanoma Skin Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||John DiGiovanni|
Nonmelanoma skin cancer (NMSC) with more than 3.5 million cases diagnosed in the U.S each year is the most common cancer and consists of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Solar ultraviolet radiation (UVA + UVB) is the primary etiologic factor for NMSC. Actinic keratosis (AKs) or solar keratoses are premalignant skin lesions with the potential to develop into SCC. The currently approved treatments for AKs include, cryosurgery and other surgical methods, topical treatment with 5-fluorouracil, diclofenac sodium, imiquimod and ingenol mebutate as well as photodynamic treatment. The current topical agents used to treat AKs have significant negative features, including ...