|Awarded On||February 18, 2015|
|Title||High-throughput Screening and Detection of Circulating Tumor Cells|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||Texas A&M Engineering Experiment Station|
|Principal Investigator/Program Director||Victor Ugaz|
|Cancer Sites||Breast, Prostate|
The technologies proposed here offer potential to deliver a transformative advance in cancer diagnostics and treatment by enabling rapid (~ 40 min) analysis and characterization of the entire cell population in a 1 mL blood sample. Unlike current methods based on antibody capture and fluorescent labeling, our approach eliminates the need for staining and permits all cells to be simultaneously probed, delivering at least a 10-fold reduction in analysis time, while simultaneously providing a wealth of currently unavailable morphological information across the entire cell population that can be mined to gain new diagnostically relevant insights. The goal of this proposal is to overcome remaini...