|Awarded On||February 18, 2015|
|Title||Effects of hormonal therapy on subclonal evolution of breast tumors with ESR1 mutations|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Suzanne A Fuqua|
The overall goals of this project are determine the role of estrogen receptor gene (ESR1) mutations in the progression and recurrence of hormone-resistant breast cancers. We originally discovered these mutations, but the paucity of reports in tumors led many to assume that ESR1 mutations were not there. It is now accepted that these mutations are indeed present in tumors with numerous recent publications validating our original discoveries. Since estrogen withdrawal with aromatase inhibitors (AIs) is the most effective endocrine therapy, and are preferred for the treatment of metastatic disease, tumors with ESR1 mutations may be resistant to estrogen withdrawal. Thus there is an urgent need ...