Grant ID RP150454
Awarded On February 18, 2015
Title Tumor Suppression Through the cGAMP/STING Pathway
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Texas Agrilife Research
Principal Investigator/Program Director Pingwei Li
Cancer Sites All Sites
Contracted Amount $900,000
Lay Summary

Our immune system is essential in protecting us against cancer. Manipulation of the host immune response is an attractive approach in cancer therapy. Interferons are important molecules in the immune system mediating antitumor and antiviral responses. However, interferons are not produced in our body under normal conditions. Bacteria or viruses can stimulate the production of interferons after they infect the host. It has been shown that the cGAMP/STING pathway activates the production of interferons. Bacterial or viral DNA can induce the activation of the cGAMP/STING pathway through the host enzyme called cGAS, which is a microbial DNA sensor in the immune system. cGAS catalyzes the synthes...

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