|Awarded On||May 20, 2015|
|Title||Acetate may be a key substrate driving growth in early stage breast cancer in patients|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Robert Bachoo|
We have studied brain tumor metabolism, looking at both primary tumors such as glioblastoma and also metastatic tumors from breast, breast, kidney cancer and melanoma. We have identified fundamental properties of these diverse types of cancer that seem to have a common theme of needing to use additional fuel for tumor growth beyond sugar. We have shown in the brain tumors that they are able to use acetate as a fuel for growth and the current work is designed to determine whether this is a common feature of tumors adapting to the brain or a fundamental characteristic of tumors. We have chosen breast cancer so that we can study patients with early stage disease who have a wide variability in t...