Grant ID RP150656
Awarded On May 20, 2015
Title Engineered Bone Targeting Nanomedicine for Treatment of Bone Metastases from Breast Cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization University of Houston
Principal Investigator/Program Director Xinli Liu
Cancer Sites Bone, Breast
Contracted Amount $122,370.70
Award Transfer Information

Previous Organization: Texas Tech University Health Sciences Center

Expended at Previous Organization: $77,599.30

Lay Summary

Breast cancer displays a very high tendency to metastasize to bone. More than 2 out of 3 patients with advanced metastatic breast cancer will develop bone metastasis; this is the major cause for severe pain, bone fractures, decreased mobility, and rapid deterioration in quality of life for patients. At present there is essentially no cure for bone metastases. Bone metastasis is a complex process involving cancer cells as well as their microenvironment in the host tissue such as bone. In this proposal, we are building new scientific synergies between nanotechnology and novel combination therapeutics, creating a two-stage bone-targeting nanomedicine containing chemotherapeutics and microRNA bo...

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