|Awarded On||May 20, 2015|
|Title||Identification of Novel Melanoma Metastasis Driver Genes through Transposon-Mediated Mutagenesis|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Kathryn O'Donnell|
Cancer is caused by mutations or alterations in DNA that promote uncontrolled cell growth or inappropriate cell survival. Melanoma is one type of cancer which affects the skin. In most cases, if the melanoma is detected early, surgery will cure the patient. However, once the melanoma spreads to distant organs of the body, in a process called metastasis, the survival of these patients drops dramatically. Our collaborators have obtained melanoma tumors directly from human patients after surgery. After transplantation of these human cells into mice, they observed that the behavior of the melanoma cells in mice predicted the clinical outcome in patients. Melanomas that efficiently metastasized i...