|Awarded On||November 19, 2015|
|Title||Visualizing T-cell trafficking|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Vikas Kundra|
Adoptive T-cell therapy is one of the most exciting avenues against cancer. It has proven efficacy. Progress is focused on improving T-cell tumor targeting to improve trafficking to tumors, preserving T-cell signaling and function, and improving persistence. However, methods for visualizing these events and for predicting response in patients are lacking. Progress has suffered from a dearth of clinically relevant, functional imaging methods for repetitively following immune cell trafficking, clonal expansion and persistence. This proposal will address these key issues for T-cell immunotherapy capitalizing upon designer somatostatin receptor-based reporter technology. No human reporter system...