|Awarded On||November 19, 2015|
|Title||Investigating the genetic and molecular mechanisms underlying RAS/ERK substrate network|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Swathi Arur|
|Cancer Sites||All Sites|
The RAS-Extracellular regulated kinase (ERK) pathway is critical for normal animal development, coordinating different processes like cell division, cell growth, cell death, and cellfate specification. Alterations in this pathway resulting in too much activity of RAS or ERK results in multiple types of cancers. ERK in turn, controls the different biological processes by controlling proteins, which it phosphorylates. These proteins are ERK targets that need to be phosphorylated to execute specific processes. However, during excessive ERK activation, some or all of these tissue specific ERK targets are also inappropriately phosphorylated, and result in mis-regulation of the processes, probably...